USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P00492 USC-OGP 2-DE database:  P00492 P00492 General information about the entry View entry in simple text format Entry name HPRT_HUMAN Primary accession number P00492 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short=HGPRTase; EC=2.4.2.8;. Gene name Name=HPRT1 Synonyms=HPRT Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1015: pI=6.08; Mw=25397 Cross-references UniProtKB/Swiss-Prot P00492; HPRT_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HPRT_HUMAN Primary accession number P00492 Secondary accession number(s) A6NHF0 B2R8M9 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 196) Name and origin of the protein Description RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short=HGPRTase; EC=2.4.2.8; Gene name Name=HPRT1 Synonyms=HPRT Encoded on Name=HPRT1; Synonyms=HPRT Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycosyltransferase; Gout; Isopeptide bond; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Purine salvage; Reference proteome; Transferase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M31642; AAA52690.1; -; mRNA EMBL M26434; AAA36012.1; -; Genomic_DNA EMBL AK313435; BAG36226.1; -; mRNA EMBL BT019350; AAV38157.1; -; mRNA EMBL AY780550; AAV31777.1; -; Genomic_DNA EMBL AC004383; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471107; EAX11761.1; -; Genomic_DNA EMBL BC000578; AAH00578.1; -; mRNA EMBL M12452; AAA52691.1; -; Genomic_DNA EMBL S79313; AAB21289.1; -; Genomic_DNA EMBL L29383; AAB59391.1; -; mRNA EMBL L29382; AAB59392.1; -; mRNA EMBL S60300; AAC60591.2; -; mRNA CCDS CCDS14641.1; -; . PIR A32728; RTHUG; . RefSeq NP_000185.1; NM_000194.2; . UniGene Hs.412707; -; . PDB 1BZY; X-ray; 2.00 A; A/B/C/D=2-218 PDB 1D6N; X-ray; 2.70 A; A/B=5-218 PDB 1HMP; X-ray; 2.50 A; A/B=2-218 PDB 1Z7G; X-ray; 1.90 A; A/B/C/D=2-218 PDB 2VFA; X-ray; 2.80 A; A/B=49-160 PDB 3GEP; X-ray; 2.60 A; A/B=2-218 PDB 3GGC; X-ray; 2.78 A; A/B=2-218 PDB 3GGJ; X-ray; 2.60 A; A/B=2-218 PDB 4IJQ; X-ray; 2.00 A; A/B/C/D=2-218 PDB 4KN6; X-ray; 2.73 A; A=3-218 PDB 4RAB; X-ray; 2.26 A; A/B/C/D=2-218 PDB 4RAC; X-ray; 2.05 A; A/B/C/D=2-218 PDB 4RAD; X-ray; 2.00 A; A/B/C/D/E/F/G/H=2-218 PDB 4RAN; X-ray; 2.55 A; A/B/C/D=2-218 PDB 4RAO; X-ray; 1.87 A; A/B/C/D=2-218 PDB 4RAQ; X-ray; 2.53 A; A/B/C/D=2-218 PDB 5BRN; X-ray; 2.30 A; A/B/C/D=1-218 PDB 5BSK; X-ray; 2.61 A; A/B/C/D=1-218 PDB 5HIA; X-ray; 1.77 A; A/B/C/D=1-218 PDBsum 1BZY; -; . PDBsum 1D6N; -; . PDBsum 1HMP; -; . PDBsum 1Z7G; -; . PDBsum 2VFA; -; . PDBsum 3GEP; -; . PDBsum 3GGC; -; . PDBsum 3GGJ; -; . PDBsum 4IJQ; -; . PDBsum 4KN6; -; . PDBsum 4RAB; -; . PDBsum 4RAC; -; . PDBsum 4RAD; -; . PDBsum 4RAN; -; . PDBsum 4RAO; -; . PDBsum 4RAQ; -; . PDBsum 5BRN; -; . PDBsum 5BSK; -; . PDBsum 5HIA; -; . ProteinModelPortal P00492; -; . SMR P00492; -; . BioGrid 109488; 27; . IntAct P00492; 15; . MINT MINT-1443310; -; . STRING 9606.ENSP00000298556; -; . BindingDB P00492; -; . ChEMBL CHEMBL2360; -; . DrugBank DB02309; 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine; . DrugBank DB04356; 9-Deazaguanine; . DrugBank DB01632; Alpha-Phosphoribosylpyrophosphoric Acid; . DrugBank DB00993; Azathioprine; . DrugBank DB01033; Mercaptopurine; . DrugBank DB00352; Tioguanine; . iPTMnet P00492; -; . PhosphoSitePlus P00492; -; . SwissPalm P00492; -; . BioMuta HPRT1; -; . DMDM 123497; -; . OGP P00492; -; . REPRODUCTION-2DPAGE IPI00218493; -; . EPD P00492; -; . MaxQB P00492; -; . PaxDb P00492; -; . PeptideAtlas P00492; -; . PRIDE P00492; -; . TopDownProteomics P00492; -; . DNASU 3251; -; . Ensembl ENST00000298556; ENSP00000298556; ENSG00000165704; . GeneID 3251; -; . KEGG hsa:3251; -; . UCSC uc004exl.5; human; . CTD 3251; -; . DisGeNET 3251; -; . GeneCards HPRT1; -; . GeneReviews HPRT1; -; . HGNC HGNC:5157; HPRT1; . HPA CAB012200; -; . HPA HPA006360; -; . MalaCards HPRT1; -; . MIM 300322; phenotype; . MIM 300323; phenotype; . MIM 308000; gene; . neXtProt NX_P00492; -; . OpenTargets ENSG00000165704; -; . Orphanet 79233; Hypoxanthine guanine phosphoribosyltransferase partial deficiency; . Orphanet 510; Lesch-Nyhan syndrome; . PharmGKB PA29427; -; . eggNOG KOG3367; Eukaryota; . eggNOG COG0634; LUCA; . GeneTree ENSGT00390000017323; -; . HOGENOM HOG000236521; -; . HOVERGEN HBG000242; -; . InParanoid P00492; -; . KO K00760; -; . OMA DIAYVGF; -; . OrthoDB EOG091G0K6K; -; . PhylomeDB P00492; -; . TreeFam TF313367; -; . BioCyc MetaCyc:HS09275-MONOMER; -; . BRENDA 2.4.2.8; 2681; . Reactome R-HSA-74217; Purine salvage; . SABIO-RK P00492; -; . UniPathway UPA00591; UER00648; . ChiTaRS HPRT1; human; . EvolutionaryTrace P00492; -; . GeneWiki Hypoxanthine-guanine_phosphoribosyltransferase; -; . GenomeRNAi 3251; -; . PRO PR:P00492; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000165704; -; . CleanEx HS_HPRT1; -; . ExpressionAtlas P00492; baseline and differential; . Genevisible P00492; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0052657; F:guanine phosphoribosyltransferase activity; IDA:UniProtKB; . GO GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IDA:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0006168; P:adenine salvage; IEA:Ensembl; . GO GO:0021954; P:central nervous system neuron development; IEA:Ensembl; . GO GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl; . GO GO:0019835; P:cytolysis; IEA:Ensembl; . GO GO:0048813; P:dendrite morphogenesis; IEA:Ensembl; . GO GO:0042417; P:dopamine metabolic process; IEA:Ensembl; . GO GO:0046038; P:GMP catabolic process; IDA:UniProtKB; . GO GO:0007625; P:grooming behavior; IEA:Ensembl; . GO GO:0006178; P:guanine salvage; IDA:UniProtKB; . GO GO:0046100; P:hypoxanthine metabolic process; IMP:UniProtKB; . GO GO:0043103; P:hypoxanthine salvage; IDA:UniProtKB; . GO GO:0046040; P:IMP metabolic process; IDA:UniProtKB; . GO GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway; . GO GO:0007626; P:locomotory behavior; IEA:Ensembl; . GO GO:0046651; P:lymphocyte proliferation; IEA:Ensembl; . GO GO:0045964; P:positive regulation of dopamine metabolic process; IMP:UniProtKB; . GO GO:0051289; P:protein homotetramerization; IDA:UniProtKB; . GO GO:0006164; P:purine nucleotide biosynthetic process; IMP:UniProtKB; . GO GO:0006166; P:purine ribonucleoside salvage; IMP:UniProtKB; . GO GO:0043101; P:purine-containing compound salvage; TAS:Reactome; . GO GO:0001975; P:response to amphetamine; IEA:Ensembl; . GO GO:0021756; P:striatum development; IEA:Ensembl; . CDD cd06223; PRTases_typeI; 1; . Gene3D 3.40.50.2020; -; 1; . InterPro IPR005904; Hxn_phspho_trans; . InterPro IPR000836; PRibTrfase_dom; . InterPro IPR029057; PRTase-like; . Pfam PF00156; Pribosyltran; 1; . SUPFAM SSF53271; SSF53271; 1; . TIGRFAMs TIGR01203; HGPRTase; 1; . PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1; .

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